Potassium Carbonate → HCID 131727922, compound

Participants

Reaction Conditions

Reaction Steps

The material from Step B (2.0 g, 3.6 mmol) was combined with [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium (II) (0.43 g, 0.53 mmol), potassium carbonate (1.5 g, 11 mmol), and 6-bromo[1,2,4]triazolo[1,5-a]pyridine (80% pure, 1.1 g, 4.3 mmol) and the flask was flushed with nitrogen. DMF (35 mL) was added, and the resulting mixture was heated at 80° C. for 14 h. The reaction mixture was diluted with ethyl acetate and washed with water. The aqueous layer was extracted with ethyl acetate and the combined organic extracts were washed with brine, dried (anhydrous sodium sulfate), and concentrated in vacuo. The residue was purified by silica gel chromatography twice (0-5% methanol in dichloromethane, then 0-5% methanol in ethyl acetate) to afford the title compound. LC/MS 547.3 (M+1).

Provenance & Evidence