HCID 131727922, compound → HCID 131727923, compound

Participants

Reaction Steps

The material from Step C (0.79 g, 1.5 mmol) was placed under 1 atmosphere of hydrogen gas in the presence of 10% palladium on carbon (1.6 g) in methanol (40 mL). After 24 h, the reaction mixture was filtered and the filtrate was concentrated in vacuo to give a mixture of cis and trans diastereomers. These diastereomers were separated by chiral HPLC (Chiralcel OD column eluting with 20% isopropanol in heptane) to afford the title compounds as single isomers (Analytical retention times: Diastereomer A Tr=11.8 min, Diastereomer B Tr=13.9 min. LC/MS 549.3 (M+1).

Provenance & Evidence