Trifluoroacetic acid → HCID 86618170, compound

Participants

Reaction Steps

To a solution of the material prepared in Step D (0.012 g, 0.028 mmol) in dichloromethane (3 mL) was added trifluoroacetic acid (1 mL). After 3 h at ambient temperature the reaction was concentrated in vacuo, affording the title compound as a white solid. 1H NMR (500 MHz, CD3OD): δ 5.41 (s, 0.5H as a single rotamer), 5.36 (s, 0.5H as a single rotamer), 5.31 (0.5H as a single rotamer), 5.26 (0.5H as a single rotamer), 4.28 (m, 1H), 4.06 (dd, J=5.5 Hz, J=9.0 Hz, 1H), 4.00 (dd, J=5.5 Hz, J=9.0 Hz, 1H), 3.78 (m, 6H), 3.64 (m, 2H), 3.51 (m, 1H), 2.90 (s, 1.5H as a single rotamer), 2.79 (s, 1.5H as a single rotamer), 2.31 (m, 2H), 2.13 (s, 3H), 2.07 (s, 3H), 1.98 (m, 2H), 1.70 (m, 6H), 1.30 (m, 2H), 0.93 (m, 3H); LC/MS 328.3 (M+1).

Provenance & Evidence