Isopropanol → Cyclohexyl-methyl-gamma-butyrolactone

Participants

Reaction Steps

In a 250 mL autoclave a mixture of 2-benzyl-γ-butyrolactone (5.00 g) and Rh-catalyst (5 wt. % Rh on carbon, 0.500 g) in isopropanol (60 mL) was treated with hydrogen (13 bar) at 120° C. for 18 h. Upon completion of the hydrogenation, the mixture was filtered and concentrated on a rotary evaporator to give 4.75 g (92%) of the title compound.

Provenance & Evidence