HCID 11423596, compound → HCID 13164942, compound

HRID 2242788Notes

Reaction equation

HRID 2242788 reaction equation
[C:1](=[C:4]1[CH2:9][CH2:8][O:7][C:5]1=[O:6])([CH3:3])[CH3:2].[H][H]>C(O)C.[Pd]>[CH:1]([CH:4]1[CH2:9][CH2:8][O:7][C:5]1=[O:6])([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 11423596HCID 11423596, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 13164942HCID 13164942, compoundYield 91%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

In a 250 mL autoclave a mixture of 2-isopropylidene-γ-butyrolactone (10.5 g) and Pd-catalyst (10 wt. % Pd on carbon, 0.050 g) in ethanol (10 mL) was treated with hydrogen (6 bar) at 60° C. for 18 h. Upon completion of the hydrogenation, the mixture was filtered and concentrated on a rotary evaporator to give 9.70 g (91%) of the title compound.

Workup

  1. filtrationUpon completion of the hydrogenation, the mixture was filtered
  2. concentrationconcentrated on a rotary evaporator

Sources & evidence

ORD record
ord-42a7a2bb49f64a80b5e05a33b97cf6fe
Source dataset
uspto-grants-2010_03
Patent number
US07674741B2

Reaction notes

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