Methylamine → HCID 68704053, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of the product from Step 1 (0.1 g, 0.33 mmol), methylamine (40% in water, 3 mL, 81 mmol) in acetonitrile (2 mL) was heated to 60° C. for 7 h, and then room temperature for 16 h. The mixture was extracted with ethyl acetate. The combined organic portions were acidified with 10% HCl to pH to 1, and stirred at 0° C. for 1 h. The product was collected on a filter, washed with 1N HCl, water and hexane. After dried under vacuum, the title compound (100 mg, 91%) was obtained as hydrochloride salt; MS (APCI) m/z 302 (M+1, 100).

Provenance & Evidence