1-Bromo-3-chloropropane → HCID 58900128, compound

Participants

Reaction Steps

The title compound was prepared from 3-chloro-2-(4-methoxy-phenyl)-2H-indazole (1.2 g, 4.9 mmol) and 1-bromo-3-chloropropane (3.1 g, 19.6 mmol), K2CO3 (2.8 g, 20.4 mmol), in methyl ethyl ketone (50 mL) was refluxed for 36 h. After the reaction mixture was diluted with water, the resulting aqueous mixture was extracted with ethyl acetate and sequentially washed with water, saturated aq. NaHCO3, water and brine. The combined organic portions were dried over Na2 SO4, filtered and concentrated in vacuo to afford the title compound (1.2 g, 80%). MS (APCI) m/z: 321 (M+1, 100).

Provenance & Evidence