Sodium Hydroxide → HCID 68703650, compound

Participants

Reaction Steps

The title compound was prepared from the product of step 1 (0.1 g, 0.28 mmol) and NaOH (50% in water, 0.080 g, 1.0 mmol) using the procedure of step 2 of the Example 3 to provide the title compound (30 mg, 30%)as a hydrochloride salt. 1H NMR (400 MHz, DMSO) δ 7.68-7.62 (m, 4H), 7.43-7.38 (m, 1H), 7.28 (d, J=8.8 Hz, 2H), 7.17 (m, 1H), 7.05 (d, J=8.8 Hz, 2H), 4.23 (t, J=5 Hz, 2H), 3.33 (br t, J=8.8 Hz, 2H), 3.17 (br t, J=8 Hz, 2H), 2.86 (s, 3H), 2.53 (t, J=6.4 Hz, 2H), 2.45 (m, 2H), 2.15 (m, 2H) LC/MS (APCI) m/z: 98%.

Provenance & Evidence