tert-Butyl bromoacetate → HCID 68707286, compound

HRID 2242871Notes

Reaction equation

HRID 2242871 reaction equation
[Cl:1][C:2]1[N:3]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][C@H:19]3[CH2:23][CH2:22][CH2:21][NH:20]3)=[CH:13][CH:12]=2)[N:4]=[C:5]2[C:10]=1[CH:9]=[CH:8][CH:7]=[CH:6]2.Br[CH2:25][C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27]>>[C:29]([O:28][C:26](=[O:27])[CH2:25][N:20]1[CH2:21][CH2:22][CH2:23][C@@H:19]1[CH2:18][O:17][C:14]1[CH:13]=[CH:12][C:11]([N:3]2[C:2]([Cl:1])=[C:10]3[C:5]([CH:6]=[CH:7][CH:8]=[CH:9]3)=[N:4]2)=[CH:16][CH:15]=1)([CH3:32])([CH3:31])[CH3:30]

Participants

3

Reactant 2

HCID 79177tert-Butyl bromoacetateHCID 11587925HCID 11587925, compound

Product 1

HCID 68707286HCID 68707286, compoundYield 82.3%

Procedure

The title compound was prepared from 3-chloro-2-[4-((R)-1-pyrrolidin-2-ylmethoxy)-phenyl]-2H-indazole (0.4 g, 1.1 mmol) and t-butyl bromoacetate (0.27 g, 1.4 mmol) using the procedure of step 7 of the Example 5 to provide the title compound (0.4 g, 80%).

Sources & evidence

ORD record
ord-09b705bbd1764f84a37722bad0cdb93a
Source dataset
uspto-grants-2010_03
Patent number
US07674802B2

Reaction notes

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