Hydrochloric Acid → HCID 68707350, compound

Participants

Reaction Steps

A mixture of the product of step 1 (0.4 g, 0.91 mmol) and HCl (4 M in dioxane, 2.3 mL, 9.1 mmol) in dioxane (5 mL)was stirred at room temperature for 16 h. After the solvent was removed, the residue was triturated with ether to provide the title compound (280 mg, 62%) as a hydrochloride salt. 1H NMR (400 MHz, DMSO) δ 7.71-7.66 (m, 4H), 7.40 (m, 1H), 7.22 (m, 3H), 4.4.50-4.27 (m, 4H), 4.04 (br, 1H), 3.70 (br, 2H), 2.28 (m, 1H), 2.04 (m, 2H), 1.98 (m, 1H), LC/MS (APCI) m/z: 94%.

Provenance & Evidence