Hydrochloric Acid → HCID 68705774, compound

Participants

Reaction Steps

A mixture of the product of step 1 (0.37 g, 0.89 mmol), water (1 mL) and HCl (4 M in dioxane, 2.3 mL, 9.1 mmol) in dioxane (5 mL) was stirred at room temperature for 16 h. After the solvent was removed, the residue was triturated with ether to provide the title compound (200 mg, 44%) as a hydrochloride salt. 1H NMR (400 MHz, CDCl3) δ 7.72-7.66 (m, 4H), 7.41 (m, 1H), 7.23 (m, 3H), 4.44 (br, 2H), 4.03 (br, 1H), 3.71 (br, 2H), 3.35 (br, 1H), 3.20 (br, 1H), 2.87 (t, J=8 Hz, 2H), 2.27 (m, 1H), 2.09-1.98 (br, 3H), LC/MS (APCI) m/z: 85%.

Provenance & Evidence