HCID 68542324, compound → HCID 68548445, compound

Participants

Reaction Steps

To a stirred solution of 4-[3-(8-amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-prop-2-ynyl]-piperazine-1-carboxylic acid tert-butyl ester (20 mg; see Example 12 above) in EtOH (1 mL) was added palladium (10 wt.% on activated carbon, ca. 5 mg). The reaction mixture was hydrogenated (45 psi) overnight, filtered through Celite and concentrated in vacuo. The resulting oil was purified by radial chromatography using 5% MeOH/CH2Cl2as eluent to afford the title compound. 1H NMR (400 MHz, CDCl3) δ 1.45 (s, 9H), 1.94 (m, 2H), 2.44 (m, 4H), 2.65 (t, 2H), 3.45 (m, 4H), 5.67 (s, 2H), 6.57 (dd, 1H), 7.13 (dd, 1H), 7.60 (s, 1H), 7.76 (s, 1H).

Provenance & Evidence