Hydrogen iodide → 2-Furan-2-yl-6-iodo-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamine

Participants

Reaction Steps

A solution of 6-bromo-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamine (600 mg; see Examples 1 and 2 above) and 57% HI (10 mL) in EtOH (50 mL) was refluxed for 1 hour. The solvent was removed in vacuo and the residue was triturated with H2O to afford 2-furan-2-yl-6-iodo-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamine as a brown solid (642 mg, 92%). 1H NMR (300 MHz, DMSO-d6) δ 6.8 (dd, J3.4, 1.8 Hz, 1H), 7.2 (dd, J=3.4, 0.8 Hz, 1H), 7.95 (s, 1H), 8.6 (s, 1H). MS: m/z 327 [M+H]+.

Provenance & Evidence