Methylamine → 3-Amino-6-bromo-N-methylpyrazine-2-carboxamide

Participants

Reaction Steps

Methyl 3-amino-6-bromo-2-pyrazine-carboxylate (14.3 g, 61.6 mmol; see Example 16 (a) above) was suspended in 40% aqueous methylamine (350 mL) and the resulting mixture was stirred vigorously for 7 hours at room temperature. The precipitate was collected, washed with water, and dried to afford 3-amino-6-bromo-pyrazine-2-carboxylic acid methylamide as a yellow solid (12.7 g, 90%). 1H NMR (300 MHz, DMSO-d6) δ2.77 (d, J=3 Hz, 3H), 7.70 (br s, 2H), 8.33 (s, 1H), 8.56 (q, J=3 Hz, 1 H); 13C NMR (100 MHz, DMSO-d6) δ27.84, 123.49, 127.69, 150.43, 156.04, 167.18.

Provenance & Evidence