Stannous chloride dihydrate → HCID 11462963, compound

Participants

Reaction Steps

To a solution of 4-(8-amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-2-methyl-1-(4-nitro-phenyl)-but-3-yn-2-ol-(17.7 mg, 0.044 mmol;. see Ex. 72 below which was prepared according to Example 24 above) in DMF (3 mL) was added SnCl2.2H2O (98 mg, 0.43 mmol) and the reaction was stirred at room temperature for overnight. The solvent was removed in vacuo and the residue was purified by reversed phase HPLC eluting with a water/acetonitrile gradient to yield the title compound (6.5 mg, 39%) as yellow solid. 1H NMR (300 MHz, DMSO) δ 8.25 (s, 1H), 7.93 (br s, 1 H), 7.60 (s, 2H), 7.33 (m, 2H), 7.14 (br s, 1H), 7.04 (m, 2H), 6.72 (br s, 1H), 2.82 (s, 2H), 1.38 (s,3 H). MS: m/z=375 amu (M++H).

Provenance & Evidence