反应详情

温度

50 °C

2.7 g (7.58 mmol) of 4-[(4-bromophenyl)-oxy]piperidine, prepared in Step 4.2, and 1.70 g (7.6 mmol) of ethyl {[(phenyloxy)carbonyl]oxy}acetate, prepared in accordance with Example 1.1, are mixed in 40 ml of toluene and the solution is heated at 50° C. for 20 hours. After cooling, it is evaporated to dryness and the product is purified by chromatography on silica gel, eluting with a 40/60 mixture of ethyl acetate and cyclohexane. The eluate is subsequently triturated in diisopropyl ether, to give 2.9 g of product in powder form.

1. customprepared in accordance with Example 1.1
2. temperatureAfter cooling
3. customit is evaporated to dryness
4. customthe product is purified by chromatography on silica gel
5. washeluting with a 40/60 mixture of ethyl acetate and cyclohexane
6. customThe eluate is subsequently triturated in diisopropyl ether