Kojic Acid → Chlorokojic acid

HRID 2242945Notes

Reaction equation

HRID 2242945 reaction equation
[CH:1]1[C:6](=[O:7])[C:5]([OH:8])=[CH:4][O:3][C:2]=1[CH2:9]O.S(Cl)([Cl:13])=O>>[Cl:13][CH2:9][C:2]1[O:3][CH:4]=[C:5]([OH:8])[C:6](=[O:7])[CH:1]=1

Participants

3

Reactant 2

HCID 3840Kojic AcidHCID 24386Thionyl Chloride

Product 1

HCID 82051Chlorokojic acid

Procedure

To Kojic acid (FLUKA, 1 g) was added thionyl chloride (ALDRICH, 1.027 mL). The yellow mixture was stirred at room temperature for 2 h. The precipitate was filtered, then washed with hexane and vacuum dried to afford 1.08 g of the title compound as a pale yellow solid.

Workup

  1. filtrationThe precipitate was filtered
  2. washwashed with hexane and vacuum
  3. customdried

Sources & evidence

ORD record
ord-91d78ef192214ab7a5d0d10d9614307d
Source dataset
uspto-grants-2010_03
Patent number
US07674808B2

Reaction notes

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