反应详情

A solution of [1-(3-ethoxy-4-methoxy-benzyl)-piperidin-4-yl]-carbamic acid tert-butyl ester (9.71 g, 26.64 mmol) in ethanol (50 mL) and 4 M HCl in dioxane (75 mL) was stirred at rt for 2 h. The hydrochloric acid was removed under reduced pressure and the crude reaction product extracted from a solution of 1 M NaOH (200 mL) with ethyl acetate (3×100 mL). The combined organic phases were dried over MgSO4 and concentrated by evaporation under reduced pressure yielding 4.69 g (89%) of a white solid. The crude material was directly used in the following reaction step. MS (ESI): 265.0 [M+H]+.

1. customThe hydrochloric acid was removed under reduced pressure
2. customthe crude reaction product
3. extractionextracted from a solution of 1 M NaOH (200 mL) with ethyl acetate (3×100 mL)
4. dry with materialThe combined organic phases were dried over MgSO4
5. concentrationconcentrated by evaporation under reduced pressure