tert-Butyl 4-((2-chloropyrimidin-4-yl)amino)piperidine-1-carboxylate → (2-Chloro-pyrimidin-4-yl)-piperidin-4-yl-amine dihydrochloride

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Reaction Steps

A solution of 4-(2-chloro-pyrimidin-4-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (3.2 g, 10.23 mmol) in ethanol (40 mL) and 4 M HCl in dioxane (70 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 213.3 [M+H]+.

Provenance & Evidence