tert-Butyl 4-((2-chloro-6-methylpyrimidin-4-yl)amino)piperidine-1-carboxylate → (2-Chloro-6-methyl-pyrimidin-4-yl)-piperidin-4-yl-amine dihydrochloride

Participants

Reaction Steps

A solution of 4-(2-chloro-6-methyl-pyrimidin-4-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (1.15 g, 3.52 mmol) in 4 M HCl in dioxane (70 mL) was stirred at rt for 1 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 225.3 [M+H]+.

Provenance & Evidence