Lithium Hydroxide → HCID 59208459, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of ethyl 4-ethylcarbamoyl-2-[6-(3-ethyl-ureido)-pyridin-3-yl]-thiazole-5-carboxylate (Example 59, 0.210 mg, 0.538 mM) in methanol (4 mL) was added 2 N lithium hydroxide (2 mL). The reaction mixture was heated to 50° C. overnight, then cooled to room temperature, and concentrated to dryness. Water was added and the pH was adjusted with 2N hydrochloric acid to pH 2. The precipitated solid was filtered and dried under vacuum to afford 0.13 g (66.6%) of the title compound as a solid. NMR: 1.11 (t, 3H), 1.23 (t, 3H), 3.19 (q, 4H), 7.71 (d, 1H), 7.81 (br s, 1H), 8.41 (d, 1H), 9.01 (s, 1H), 9.66 (s, 1H), 9.83 (br s, 1H).

Provenance & Evidence