HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiourea → Methyl 4-(2-aminothiazol-4-yl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | Methyl 4-(2-bromoacetyl)benzoate | HCID 13612771 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 4-(2-aminothiazol-4-yl)benzoate | HCID 2060012 | — |
Reaction Steps
Methyl 4-(bromoacetyl)benzoate (300 mg, 1.17 mmol) and thiourea 110 mg, 1.40 mmol) were taken in MeOH (5 ml) and refluxed for 2 hours. The precipitated product was collected by filtration, washed with MeOH and dried (260 g). MS (ESP): 235 (M+H+) for C11H10N2O2S; NMR: 3.87 (s, 3H), 7.38 (s, 1H), 7.90 (d, 2H), 8.01 (d, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07674801B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-b41dcbfe9fd54ee9a6a4006d75b52476 |
| Source note | uspto-grants-2010_03 |