Formic Acid → HCID 59208360, compound

Participants

Reaction Steps

Formic acid (0.628 mL, 16.5 mmoles) and 30% hydrogen per oxide (1.87 mL, 16.5 mmoles) were added to 6-chloro-4-formyl-N,N-dimethyl-nicotinamide (Intermediate 67, 0.7 g. 3.3 mmoles), and the solution was kept at 4° C. for 4 days. The precipitate was filtered and washed with cold water. The solid was heated to reflux in toluene then collected by filtration (2×25 mL) to afford 0.28 g (35.89%) of the title compound as pale yellow solid. MS (APCI): 229 (M+H+) for C9H9ClN2O3; NMR: 2.76 (s, 3H), δ 2.97 (s, 3H), δ 7.84 (s, 1H), δ 8.47 (s, 1H).

Provenance & Evidence