Sodium Hydroxide → HCID 178524236, compound

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Reaction Steps

2M NaOH (75 ml) is added, at 0° C., to methyl 4-(5-nitro-1H-benzimidazol-2-yl)benzoate (15 g, 0.050 mol) (Example 26) in methanol (250 ml). The mixture is stirred at room temperature for 20 hours and evaporated, and the residue is taken up in water and acidified with HCl (pH=6). The resulting mixture is stirred for 16 hours at 0° C., and the product is filtered off, washed with water and recrystallized from 9/1 methanol/isopropyl ether. Yield: 10 g (70%); IR (KBr): 3357, 1675, 1602, 1537, 1377, 1320 cm−1; 1H-NMR (d6-DMSO) 7.5-8.6 (m, 7H).

Provenance & Evidence