HCID 23085720, compound → HCID 178526438, compound

Participants

Reaction Steps

N-Benzoyl-2-amino-5-nitrobenzylamine (33 g, 0.12 mol) and phosphoryl chloride (150 ml) are refluxed for 3 hours. The mixture is concentrated and water is added, followed by addition of aqueous ammonia (pH>10). The product is filtered off and recrystallized from water, and then from 2/1 isopropyl ether/hexane. Yield: 27.6 g (89%); IR (KBr): 3387, 3198, 1599, 1512, 1341 cm−1; 1H-NMR (d6-DMSO) 7.95 (m, 4H); 7.30 (m, 4H); 7.01 (m, 1H); 4.71 (s, 2H).

Provenance & Evidence