(4-Fluoro-3-phenoxyphenyl)methanol → N-(4-methylphenyl)valine

HRID 224320Notes

Reaction equation

HRID 224320 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]([CH:13]([CH3:15])[CH3:14])[C:11](=[O:16])[O:10]C2=O)=[CH:4][CH:3]=1.FC1C=CC(CO)=CC=1OC1C=CC=CC=1>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C@H:12]([C:11]([OH:16])=[O:10])[CH:13]([CH3:15])[CH3:14])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 12874224(4-Fluoro-3-phenoxyphenyl)methanolHCID 202892893-(4-Methylphenyl)-4-isopropyloxazolidine-2,5-dione

Product 1

HCID 53646739N-(4-methylphenyl)valine

Procedure

Following the above procedure, 3-(4-methylphenyl)-4-isopropyloxazolidine-2, 5-dione is reacted with 4-fluoro-3-phenoxybenzyl alcohol to give the 4-fluoro-3-phenoxybenzyl ester of N-(4-methylphenyl) valine.

Sources & evidence

ORD record
ord-cda6c4b37d5646b4a3297a173e501e96
Source dataset
uspto-grants-1980_11
Patent number
US04231953

Reaction notes

Loading…