Ethyl 2-bromopropionate → HCID 68510681, compound

HRID 2243206Notes

Reaction equation

HRID 2243206 reaction equation
Br[CH:2]([CH3:8])[C:3]([O:5][CH2:6][CH3:7])=[O:4].C(OC(=O)C[N:14]1[CH2:18][C:17]([CH3:20])([CH3:19])[CH:16]([O:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]#[N:29])=[C:24]([C:30]([F:33])([F:32])[F:31])[CH:23]=2)[C:15]1=[O:34])C>>[CH2:6]([O:5][C:3](=[O:4])[CH:2]([N:14]1[CH2:18][C:17]([CH3:20])([CH3:19])[CH:16]([O:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]#[N:29])=[C:24]([C:30]([F:32])([F:33])[F:31])[CH:23]=2)[C:15]1=[O:34])[CH3:8])[CH3:7]

Participants

3

Reactant 2

HCID 79040Ethyl 2-bromopropionateHCID 56680440HCID 56680440, compound

Product 1

HCID 68510681HCID 68510681, compound

Procedure

The reaction was carried out as previously described in Step 1 of examples 111-127 using ethyl 2-bromopropionate in place of bromoacetic acid ethyl ester. The diastereomeric mixture of products (3) were separated by column chromatography to afford the diastereomers as either the RS or SR compound or the RR or SS compound. The RS or SR compound was used in the next reaction.

Workup

  1. customwere separated by column chromatography
  2. customto afford the diastereomers as either the RS or SR compound
  3. customThe RS or SR compound was used in the next reaction

Sources & evidence

ORD record
ord-ac2d44ed03fe4e1c972f4752249aa0fd
Source dataset
uspto-grants-2010_03
Patent number
US07674819B2

Reaction notes

Loading…