Ethanolamine → HCID 136353746, compound

HRID 2243223Notes

Reaction equation

HRID 2243223 reaction equation
[CH2:1]([NH2:4])[CH2:2][OH:3].[CH3:5][C:6]1[NH:10][C:9](=[O:11])[N:8]([C:12]2[CH:17]=[CH:16][C:15]([S:18][C:19]3[CH:20]=[C:21]([C:25]4([C:31](OCC)=[O:32])[CH2:30][CH2:29][O:28][CH2:27][CH2:26]4)[CH:22]=[CH:23][CH:24]=3)=[CH:14][CH:13]=2)[N:7]=1>C(O)C>[OH:3][CH2:2][CH2:1][NH:4][C:31]([C:25]1([C:21]2[CH:22]=[CH:23][CH:24]=[C:19]([S:18][C:15]3[CH:16]=[CH:17][C:12]([N:8]4[C:9](=[O:11])[NH:10][C:6]([CH3:5])=[N:7]4)=[CH:13][CH:14]=3)[CH:20]=2)[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1)=[O:32]

Participants

4

Reactant 2

HCID 700EthanolamineHCID 136353839HCID 136353839, compound

Product 1

HCID 136353746HCID 136353746, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Ethanolamine (6.0 mmol) is added to a solution of ethyl 4-(3-{[4-(3-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phenyl]thio}phenyl)tetrahydro-2H-pyran-4-carboxylate (1.0 mmol) (example 19) in ethanol and the mixture are refluxed. All the volatiles are removed under reduced pressure and the residue is purified by column chromatography over silica gel to afford the title compound.

Workup

  1. temperaturethe mixture are refluxed
  2. customAll the volatiles are removed under reduced pressure
  3. customthe residue is purified by column chromatography over silica gel

Sources & evidence

ORD record
ord-3bf0342b95794bde85ca816b29ebf1e7
Source dataset
uspto-grants-2010_03
Patent number
US07674811B2

Reaction notes

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