Sodium Hydroxide → HCID 58883234, compound

HRID 2243228Notes

Reaction equation

HRID 2243228 reaction equation
C[O:2][C:3](=[O:23])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[O:11][C:12]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[CH:13][C:14](=[O:16])[CH:15]=2)[CH:5]=1.[OH-].[Na+:25]>CO>[Na+:25].[N:17]1([C:12]2[O:11][C:10]([C:6]3[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=3)[C:3]([O-:23])=[O:2])=[CH:15][C:14](=[O:16])[CH:13]=2)[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 16203592HCID 16203592, compound

Product 1

HCID 58883234HCID 58883234, compoundYield 83.33%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3-(6-Morpholin-4-yl-4-oxo-4H-pyran-2-yl)-benzoic acid methyl ester (5.42 g, 17.20 mmol) was dissolved in methanol (25 ml) and sodium hydroxide (0.75 g, 18.90 mmol) was added. The stirred solution was then refluxed under nitrogen for three hours. The methanol was removed in vacuo and the residue was triturated in ether to give the title compound as a brown solid (4.30 g, 83.33%). m/z (LC-MS, ESP): 301 (M++1).

Workup

  1. temperatureThe stirred solution was then refluxed under nitrogen for three hours
  2. customThe methanol was removed in vacuo
  3. customthe residue was triturated in ether

Sources & evidence

ORD record
ord-f19b3892ae9d47f1897d3c08cfafa695
Source dataset
uspto-grants-2010_03
Patent number
US07674823B2

Reaction notes

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