Sodium Hydroxide → HCID 58883240, compound

HRID 2243230Notes

Reaction equation

HRID 2243230 reaction equation
C[O:2][C:3](=[O:23])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:11][C:12]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[CH:13][C:14](=[O:16])[CH:15]=2)=[CH:6][CH:5]=1.[OH-].[Na+:25]>CO>[Na+:25].[N:17]1([C:12]2[O:11][C:10]([C:7]3[CH:8]=[CH:9][C:4]([C:3]([O-:23])=[O:2])=[CH:5][CH:6]=3)=[CH:15][C:14](=[O:16])[CH:13]=2)[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 16203593HCID 16203593, compound

Product 1

HCID 58883240HCID 58883240, compoundYield 97.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-(6-Morpholin-4-yl-4-oxo-4H-pyran-2-yl)-benzoic acid methyl ester (3.00 g, 9.52 mmol) was dissolved in methanol (20 ml) and sodium hydroxide (0.381 g, 9.52 mmol) was added. The stirred solution was then refluxed under nitrogen for three hours. The methanol was removed in vacuo and the residue was triturated in ether to give the title compound as a brown solid (3 g, 97%). m/z (LC-MS, ESP): 301 (M++1).

Workup

  1. temperatureThe stirred solution was then refluxed under nitrogen for three hours
  2. customThe methanol was removed in vacuo
  3. customthe residue was triturated in ether

Sources & evidence

ORD record
ord-1859e719748d4ea1a39b817819a79177
Source dataset
uspto-grants-2010_03
Patent number
US07674823B2

Reaction notes

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