4-Toluenesulfonyl chloride → HCID 72315987, compound

Participants

Reaction Steps

Tosyl chloride (11.60 g, 60.80 mmol) was added in small portions to a stirred solution of 1-(2-Hydroxy-ethylamino)-propan-2-ol (3.60 g, 30.25 mmol) in anhydrous pyridine at 0° C. The reaction was stirred at room temperature for 24 h and then poured onto ice-water (200 ml). The mixture was extracted into DCM (100 ml). The organic extract washed with 2N HCl, water, and was evaporated in vaccuo to give a brown residue which was used without further purification.

Provenance & Evidence