HRID224324

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID20236070

未命名化合物

HCID20283983

未命名化合物

HCID53813367

未命名化合物

PRODUCTS

生成物

结构：CC(C)C(Nc1ccc(C(F)(F)F)cc1F)C(=O)OCc1cc(F)cc(Oc2ccccc2)c1

HCID53707768

未命名化合物

结构：CC(C)C(Nc1ccc(C(F)(F)F)cc1F)C(=O)OC(C#N)c1cc(Oc2ccccc2)ccc1F

HCID54005306

未命名化合物

PROCEDURE

实验过程

The alcohol, α-cyano-2-fluoro-5-phenoxybenzyl alcohol and 3-fluoro-5-phenoxybenzyl alcohol, is reacted with 2-(2-fluoro-4-trifluoromethylphenylamino)-3-methylbutanoic acid to yield α-cyano-2-fluoro-5-phenoxybenzyl 2-(2-fluoro-4-trifluoromethylphenylamino)3-methylbutanoate and 3-fluoro-5-phenoxybenzyl 2-(2-fluoro-4-trifluoromethylphenylamino)-3-methylbutanoate, respectively.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4dafdcfd533f4d36962db01448e78805
来源数据集: uspto-grants-1980_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04231953
来源说明: uspto-grants-1980_11

反应 SMILES

[C:1]([CH:3]([OH:18])[C:4]1[CH:9]=[C:8]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=[CH:6][C:5]=1[F:17])#[N:2].[F:19][C:20]1[CH:21]=[C:22]([CH:25]=[C:26]([O:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:27]=1)[CH2:23][OH:24].[F:35][C:36]1[CH:41]=[C:40]([C:42]([F:45])([F:44])[F:43])[CH:39]=[CH:38][C:37]=1[NH:46][CH:47]([CH:51]([CH3:53])[CH3:52])[C:48](O)=[O:49]>>[F:35][C:36]1[CH:41]=[C:40]([C:42]([F:45])([F:44])[F:43])[CH:39]=[CH:38][C:37]=1[NH:46][CH:47]([CH:51]([CH3:53])[CH3:52])[C:48]([O:18][CH:3]([C:1]#[N:2])[C:4]1[CH:9]=[C:8]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=[CH:6][C:5]=1[F:17])=[O:49].[F:35][C:36]1[CH:41]=[C:40]([C:42]([F:45])([F:44])[F:43])[CH:39]=[CH:38][C:37]=1[NH:46][CH:47]([CH:51]([CH3:53])[CH3:52])[C:48]([O:24][CH2:23][C:22]1[CH:25]=[C:26]([O:28][C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:27]=[C:20]([F:19])[CH:21]=1)=[O:49]