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Iodine → 4-Iodo-2-(trifluoroacetyl)pyrrole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Iodine | HCID 807 | — |
| 反応物 | Ethanone, 2,2,2-trifluoro-1-(1H-pyrrol-2-yl)- | HCID 137637 | — |
| 反応物 | Dicerium ammonium nitrate | HCID 86617141 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 4-Iodo-2-(trifluoroacetyl)pyrrole | HCID 59210406 | 112.1% |
反応手順
An acetonitrile solution (20 ml) of 2-(trifluoroacetyl)-1H-pyrrole (0.5 g), dicerium ammonium nitrate (0.84 g) and iodine (0.47 g) was refluxed for 2 hours. After cooling, the reaction solution was washed with saturated aqueous solution of sodium thiosulfate and saturated aqueous solution of sodium chloride. After drying the organic layer with magnesium sulfate, the solvent was distilled off under the reduced pressure to obtain 4-iodo-2-(trifluoroacetyl)-1H-pyrrole (0.6 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07674807B2 |
| 出典データセット | uspto-grants-2010_03 |
| ORD ID | ord-5a43c9b40c4a49bdb194188d71139fae |
| 出典メモ | uspto-grants-2010_03 |