HRID2243264

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID140764

3H,3H-Perfluoro-2,4-hexanedione

C6H2F8O2

HCID13158578

(3-Methyl-4-nitrophenyl)hydrazine

C7H9N3O2

PRODUCTS

生成物

结构：Cc1cc(N2N=C(C(F)(F)C(F)(F)F)CC2(O)C(F)(F)F)ccc1[N+](=O)[O-]

HCID59210397

未命名化合物

结构：Cc1cc(-n2nc(C(F)(F)C(F)(F)F)cc2C(F)(F)F)ccc1[N+](=O)[O-]

HCID59210421

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

(3-Methyl-4-nitro-phenyl)-hydrazine (2.0 g) and 1,1,1,5,5,6,6,6-octafluoro-2,4-hexanedione (3.1 g) were dissolved in toluene and the solution was refluxed for 6 hours. After cooling, the solvent was distilled off and the obtained residue was purified by silica gel column chromatography to obtain 1-(3-methyl-4-nitro-phenyl)-3-pentafluoroethyl-5-trifluoromethyl-1H-pyrazole (IX-3) (3.0 g) and 2-(3-methyl-4-nitro-phenyl)-5-pentafluoroethyl-3-trifluoromethyl-3,4-dihydro-2H-pyrazol-3-ol (IX-4) (0.5 g), respectively.

WORKUP

后处理

temperaturethe solution was refluxed for 6 hours
temperatureAfter cooling
distillationthe solvent was distilled off
customthe obtained residue was purified by silica gel column chromatography

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b9e65915bbda42ae80e60d6fb993e08e
来源数据集: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07674807B2
来源说明: uspto-grants-2010_03

反应 SMILES

[CH3:1][C:2]1[CH:3]=[C:4]([NH:11][NH2:12])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[F:13][C:14]([F:28])([F:27])[C:15](=[O:26])[CH2:16][C:17](=O)[C:18]([F:24])([F:23])[C:19]([F:22])([F:21])[F:20]>C1(C)C=CC=CC=1>[CH3:1][C:2]1[CH:3]=[C:4]([N:11]2[C:15]([C:14]([F:28])([F:27])[F:13])=[CH:16][C:17]([C:18]([F:23])([F:24])[C:19]([F:20])([F:21])[F:22])=[N:12]2)[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[CH3:1][C:2]1[CH:3]=[C:4]([N:11]2[C:15]([C:14]([F:28])([F:27])[F:13])([OH:26])[CH2:16][C:17]([C:18]([F:23])([F:24])[C:19]([F:20])([F:21])[F:22])=[N:12]2)[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9]