Iodine → HCID 178506332, compound

HRID 2243279Notes

Reaction equation

HRID 2243279 reaction equation
[F:1][C:2]([F:12])([C:7]1[CH:11]=[CH:10][NH:9][N:8]=1)[C:3]([F:6])([F:5])[F:4].[N+]([O-])([O-])=O.[NH4+].[Ce].[Ce].[I:20]I>C(#N)C>[I:20][C:11]1[C:7]([C:2]([F:1])([F:12])[C:3]([F:6])([F:5])[F:4])=[N:8][NH:9][CH:10]=1

Participants

5

Reactant 3

HCID 807IodineHCID 86617141Dicerium ammonium nitrateHCID 1785063263-(pentafluoroethyl)-1H-pyrazole

Product 1

HCID 178506332HCID 178506332, compoundYield 162.7%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

An acetonitrile solution (20 ml) of 3-pentafluoroethyl-1H-pyrazole (2.0 g), dicerium ammonium nitrate (3.0 g) and iodine (1.6 g) was refluxed for 3 hours. After cooling, the reaction solution was washed with saturated aqueous solution of sodium thiosulfate and saturated aqueous solution of sodium chloride. After drying the organic layer with magnesium sulfate, the solvent was distilled off under the reduced pressure to obtain 4-iodo-3-pentafluoroethyl-1H-pyrazole (3.2 g).

Workup

  1. temperatureAfter cooling
  2. washthe reaction solution was washed with saturated aqueous solution of sodium thiosulfate and saturated aqueous solution of sodium chloride
  3. dry with materialAfter drying the organic layer with magnesium sulfate
  4. distillationthe solvent was distilled off under the reduced pressure

Sources & evidence

ORD record
ord-616beeebfdde422abc9d876986fc83e7
Source dataset
uspto-grants-2010_03
Patent number
US07674807B2

Reaction notes

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