Water → HCID 59210614, compound

Participants

Reaction Conditions

Reaction Steps

At 0° C., 140 mg (0.51 mmol) of phosphorus tribromide were added to a solution of 500 mg (1.14 mmol) of methyl 8-{2-[(4-cyclohexylbenzyl)oxy]phenyl}-6-hydroxyoctanoate XVI in 5 ml of diethyl ether. The mixture was stirred at 0° C. for 1 h and at room temperature for another 16 h. Water was added, the mixture was extracted with cyclohexane and the combined organic phases were dried over Na2SO4. The product was purified chromatographically (silica gel, cyclohexane(ethyl acetate 10:1).

Provenance & Evidence