Water → HCID 59210688, compound

Participants

Reaction Steps

Under argon, 102.8 mg (0.32 mmol) of 4-bromomethyl-2-(3-fluorophenyl)-benzothiazole and 300 mg of MS3A are dissolved in 5 ml of benzene. At room temperature, 82 mg (0.27 mmol) of methyl 6-hydroxymethyl-7-(4-methoxycarbonyl-phenyl)heptanoate (synthesis cf. EP-A-0 341 551, p. 31, Ex. 42) and 92 mg (0.40 mmol) of silver oxide are added. The mixture is stirred at room temperature for 6 days. About 0.2 ml of water is added, the mixture is filtered through Extrelut, which is washed with toluene, and the filtrate is concentrated under reduced pressure and chromatographed.

Provenance & Evidence