Hydrochloric Acid → HCID 59208193, compound

Participants

Reaction Steps

Dissolve 144 mg of tert-butyl ester of {(R)-1-carbamoyl-2-[4-(3H-imidazo[4,5-c]pyridin-2-yl)-9H-fluoren-9(R,S)-ylcarbamoyl]-ethyl}-carbamoic acid, obtained in Example 59, in 5 ml of dioxan and add 1 ml of a 4M solution of hydrochloric acid in dioxan. After stirring for 5 hours at room temperature, dry the solid that formed. After washing successively with a saturated aqueous solution of sodium hydrogen carbonate, then with dichloromethane, we obtain 145 mg of (R)-2-amino-N4-[4-(3H-imidazo[4,5-c]pyridin-2-yl)-9H-fluoren-9(R,S)-yl]-succinamide, in the form of a pale green, crystalline solid, with the following characteristics:

Provenance & Evidence