HCID 136385295, compound → HCID 59208162, compound

Participants

Reaction Steps

Carry out the procedure as in Example 6, starting from 1.7 g of 4-(6-fluoro-1H-benzimidazol-2-yl)-fluoren-9-one oxime (Z,E), obtained in Example 70, and 6 mg of Raney Nickel in 90 ml of ethanol and 90 ml of tetrahydrofuran for 4 hours at 60° C. under a hydrogen pressure of 1 bar. After purification by making a paste in diisopropyl ether, we obtain 1.58 g of 4-(6-fluoro-1H-benzimidazol-2-yl)-9H-fluoren-9(R,S)-ylamine, in the form of a beige powder with the following characteristics:

Provenance & Evidence