Dimethylformamide → Diisopropyl Ether

Participants

Reaction Steps

Carry out the procedure as in Example 14, starting from 200 mg of 4-(3H-imidazo[4,5-c]pyridin-2-yl)-fluorene-9(R,S)-amine, obtained in Example 6, and 138 mg of 2-methyl-quinoline-5-carboxylic acid, which can be obtained according to J. Med. Chem. 2002, 4647, in the presence of 128.4 mg of EDCI and 90.5 mg of HOBT in 5.5 ml of DMF for 20 hours. After purification by washing successively with a saturated aqueous solution of sodium hydrogen carbonate then with water and diisopropyl ether, we obtain 70 mg of [4-(3H-imidazo[4,5-c]pyridin-2-yl)-9H-fluoren-9-yl]amide of 2-methyl-quinoline-5-carboxylic acid, in the form of a pale yellow powder, with the following characteristics:

Provenance & Evidence