HCID 137227828, compound → HCID 67359907, compound

Participants

Reaction Steps

Carry out the procedure as in Example 6, starting from 900 mg of 4-(6-methoxy-1H-benzimidazol-2-yl)-9H-fluoren-9-one oxime (Z,E), obtained in the preceding stage, and 1.55 mg of Raney Nickel in 50 ml of ethanol and 50 ml of tetrahydrofuran for 16 hours at 60° C. under a hydrogen pressure of 1 bar. After purification by making a paste in diisopropyl ether, we obtain 631 mg of 4-(6-methoxy-1H-benzimidazol-2-yl)-9H-fluoren-9(R,S)-ylamine, in the form of a brown powder, with the following characteristics:

Provenance & Evidence