HCID 137227830, compound → HCID 67359277, compound

Participants

Reaction Steps

Carry out the procedure as in Example 6, starting from 500 mg of 4-(6-hydroxy-1H-benzimidazol-2-yl)-fluoren-9-one oxime (Z,E), obtained in Example 107, and 5 mg of Raney Nickel in 25 ml of ethanol and 25 ml of tetrahydrofuran for 5 hours at 60° C. under a hydrogen pressure of 1 bar. After purification by making a paste in diisopropyl ether, we obtain 385 mg of 4-(6-hydroxy-1H-benzimidazol-2-yl)-fluoren-9(R,S)-ylamine, in the form of a brown powder, with the following characteristics:

Provenance & Evidence