HCID 137227833, compound → HCID 77272935, compound

Participants

Reaction Steps

The procedure used in Example 6 is followed, but starting from 4 g of 4-(4-methyl-1H-benzimidazol-2-yl)-9H-fluoren-9-one oxime (Z,E), obtained in the previous stage, and 0.7 g of Raney nickel in 100 ml of ethanol and 100 ml of tetrahydrofuran for 10 hours at 60° C. under an initial hydrogen pressure of one bar. After filtration of the catalyst, and then purification by formation of a paste in diisopropyl ether, in this way we obtain 2.7 g of 4-(4-methyl-1H-benzimidazol-2-yl)-9H-fluoren-9(R,S)-ylamine, in the form of a beige powder which is used as it is in the following stage.

Provenance & Evidence