HCID 137227835, compound → HCID 77272886, compound

Participants

Reaction Steps

The procedure used in Example 6 is followed, but starting from 4 g of 4-(4,5-difluoro-1H-benzimidazol-2-yl)-9H-fluoren-9-one oxime (Z,E), obtained in the previous stage, and 0.27 g of Raney nickel in 35 ml of ethanol and 35 ml of tetrahydrofuran for 10 hours at 60° C. under an initial hydrogen pressure of one bar. After filtration of the catalyst, and purification by forming a paste in diisopropyl ether, in this way we obtain 1 g of 4-(4,5-difluoro-1H-benzimidazol-2-yl)-9H-fluoren-9(R,S)-ylamine, in the form of a beige powder which is used as it is in the following stage.

Provenance & Evidence