Phenylacetyl chloride → Acetamide, N-(2-(5-methoxyindan-6-yl)ethyl)-2-phenyl-

HRID 224333Notes

Reaction equation

C(=O)(O)[O-].[K+].[C:6]1([CH2:12][C:13](Cl)=[O:14])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[NH2:16][CH2:17][CH2:18][C:19]1[CH:20]=[C:21]2[C:25](=[CH:26][C:27]=1[O:28][CH3:29])[CH2:24][CH2:23][CH2:22]2>>[C:6]1([CH2:12][C:13]([NH:16][CH2:17][CH2:18][C:19]2[CH:20]=[C:21]3[C:25](=[CH:26][C:27]=2[O:28][CH3:29])[CH2:24][CH2:23][CH2:22]3)=[O:14])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

Reactant 3

HCID 7679Phenylacetyl chloride

HCID 516893Potassium Bicarbonate

HCID 12426123HCID 12426123, compound

Product 1

HCID 49798Acetamide, N-(2-(5-methoxyindan-6-yl)ethyl)-2-phenyl-

Procedure

Using the procedure of Example 1, but with potassium bicarbonate replacing triethylamine, phenylacetyl chloride was reacted with 5-aminoethyl-6-methoxyindan to produce the desired product. After recrystallization from ether it had a melting point of 135° C.

Sources & evidence

ORD record: ord-fcfcb7d0f5ae4c35ad789873ec611082
Source dataset: uspto-grants-1980_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04232014

Reaction notes

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