9-Oxofluorene-4-carboxylic acid → HCID 67360748, compound

Participants

Reaction Steps

A mixture of 1.61 g of (2-amino-4-bromophenyl)amide of 9-oxo-9H-fluorene-4-carboxylic acid in 80 ml of glacial acetic acid is refluxed for 2.5 hours. Allow to return to ambient temperature and evaporate the reaction medium to dryness under vacuum. The residue is taken up with 50 ml of dichloromethane, and the organic phase is washed with twice 50 ml of a saturated solution of sodium bicarbonate and 50 ml of a saturated solution of sodium chloride. After drying over magnesium sulphate, the organic phase is evaporated to dryness under vacuum. The residue is chromatographed on silica gel, eluting with a mixture of methanol and dichloromethane (5/95 by volume). In this way, we obtain 1.5 g of 4-(6-bromo-1H-benzimidazol-2-yl)-9H-fluoren-9-one, with the following characteristics:

Provenance & Evidence