HCID 137227841, compound → HCID 131727952, compound

Participants

Reaction Steps

The procedure used in Example 6 is followed, but starting from 250 mg of 5-[1-(tert-butoxycarbonyl)benzimidazol-2-yl]-7-( tert-butoxycarbonyl-amino)-9H-fluoren-9-one oxime (Z,E), obtained in the previous stage, and 29 mg of Raney nickel in 4 ml of ethanol and 4 ml of tetrahydrofuran for 10 hours at 60° C. under an initial hydrogen pressure of one bar. After filtration of the catalyst, and purification by formation of a paste in diisopropyl ether, in this way we obtain 250 mg of 5-[1-(tert-butoxycarbonyl)benzimidazol-2-yl]-7-(tert-butoxycarbonylamino)-9H-fluoren-9(R,S)-ylamine, in the form of an orange powder which is used as it is in the following stage.

Provenance & Evidence