Triethylamine → (2-Amino-4-methoxyphenyl)amide

Participants

Reaction Steps

The procedure used in stage 1 of Example 1 is followed, but starting from 10 g of 1,2-diamino-4-methoxybenzene, 20 ml of triethylamine and 17 g of fluoren-4-one-9-carboxylic acid chloride in 600 ml of dichloromethane. After stirring for 20 hours at room temperature, the precipitate that formed is filtered off, and washed with dichloromethane, with water, then with a 10% saturated aqueous solution of sodium hydrogen carbonate and, finally, with water. After formation of a paste with diisopropyl ether, in this way we obtain 6.2 g of (2-amino-4-methoxyphenyl)amide of 9-oxo-9H-fluorene-4-carboxylic acid, in the form of a brown powder, which is used as it is in the following stage, with the following characteristics:

Provenance & Evidence