9-Oxofluorene-4-carboxylic acid → HCID 67361020, compound

Participants

Reaction Steps

The procedure used in Example 68 is followed. In a 250 ml round-bottomed flask under an argon atmosphere, reflux, for 6 hours, a suspension of 4 g of [2-amino-4-(4-methylpiperazin-1-yl)phenyl]amide of 9-oxo-9H-fluorene-4-carboxylic acid, obtained in the previous stage, in 64 ml of acetic acid. After purification by formation of a paste with diisopropyl ether, in this way we obtained 2.5 g of 4-[6-(4-methylpiperazin-1-yl)-1H -benzimidazol-2-yl]-9H-fluoren-9-one, in the form of an orange powder, which is used as it is in the following stage, with the following characteristics:

Provenance & Evidence