HCID 136385190, compound → HCID 77272903, compound

Participants

Reaction Steps

The procedure used in Example 6 is followed, but starting from 1.5 g of 4-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-9H-fluoren-9-one oxime (Z,E), obtained in the previous stage, and 229 mg of Raney nickel in 35 ml of ethanol and 35 ml of tetrahydrofuran for 48 hours at 60° C. under an initial hydrogen pressure of one bar. After filtration of the catalyst, concentration to dryness under reduced pressure and purification by formation of a paste in diisopropyl ether, in this way we obtained 1.3 g of 4-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-9H-fluoren-9(R,S)-ylamine, in the form of an orange powder, which is used as it is in the following stage, with the following characteristics:

Provenance & Evidence